Genome-wide association study of neuropsychiatric symptoms in dementia

 
   Lead Investigator:    Byron Creese
   Institution      :    University of Exeter
   E-Mail           :    b.creese@exeter.ac.uk
   Proposal ID      :    916


   Publications:


1  Creese B, Vassos E, Bergh S, Athanasiu L, Johar I, Rongve A, Tøndel Medbøen I, Da Silva V, Aakhus E, Andersen F, Bettella F, Braekhus A, Djurovic S, Paroni G, Proitsi P, Saltvedt I, Seripa D, Stordal E, Fladby T, Aarsland D, Andreassen OA, Ballard C, Selbaek G
   Examining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer's disease
   Journal Article  Transl Psychiatry,9:273,2019,PMC6805870

   PUBLISHED





   Proposal Description:
   -  There is strong evidence of a genetic component to psychosis risk in AD and    suggestive evidence of such a relationship in other neuropsychiatric symptoms.    However, to date all published GWAS of any neuropsychiatric symptom in AD have    been under-powered, leaving a significant gap in our ability to identify          potential disease mechanisms associated with these symptoms.                      -  We will combine suitable cases from the NACC with our existing large           collection (exceeding 5000) of cases in order to conduct the largest GWAS of      neuropsychiatric symptoms in AD to date.                                          -  We will test the hypothesis that key neuropsychiatric symptoms in AD have      distinct biological correlates as reflected by a specific pattern of genetic      risk when compared to AD without these symptoms.                                  -  We also plan to conduct the first preliminary investigations of the genetics   of similar symptoms which occur in dementia with Lewy bodies, again by            combining available data from the NACC with our own collections.